Detalle de: Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme
| Title | Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme |
| Abstract |
The first example of a hydroxylammonium derivative that causes a specific covalent modification of the active-site lysine residue of an aldolase enzyme, which is a promising target for anti-bacterial drug discovery, is reported. |
| Apa Reference | Maneiro, M., Lence, E., Sanz-Gaitero, M., Otero, J. M., van Raaij, M. J., Thompson, P., Hawkins, A. R., & González-Bello, C. (2019). Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme. Organic Chemistry Frontiers, 6(17), 3127–3135. 10.1039/c9qo00453j |
| Doi | 10.1039/C9QO00453J |
| Publication Date | 2019 |
| Publication Type | Article |
| Researcher | Mark van Raaij |
| Ontology | Drug Discovery and design |
| Research Groups | Structural Biology of Virus Proteins |
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