Detalle de: 'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile
| Title | 'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile |
| Abstract |
A series of gramicidin S derivatives 4-15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino acids with unaltered turn regions. These peptides were screened against human erthrocytes and our standard panel of Gram negative- and Gram positive bacteria, including four MRSA strains. Based on the antibacterial- and hemolytic data, peptides 13 and 14 have an improved biological profile compared to the clinically applied topical antibiotic gramicidin S. |
| Apa Reference | Kapoerchan, V. V., Knijnenburg, A. D., Keizer, P., Spalburg, E., de Neeling, A. J., Mars-Groenendijk, R. H., Noort, D., Otero, J. M., Llamas-Saiz, A. L., van Raaij, M. J., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2012). ‘Inverted’ analogs of the antibiotic gramicidin S with an improved biological profile. Bioorganic & Medicinal Chemistry, 20(20), 6059–6062. 10.1016/j.bmc.2012.08.038 |
| Doi | 10.1016/j.bmc.2012.08.038 |
| Publication Date | Oct 2012 |
| Publication Type | Article |
| Researcher | Mark van Raaij |
| Ontology | |
| Research Groups | Structural Biology of Virus Proteins |
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