Detalle de: Computational protein design methods for synthetic biology
| Title | Computational protein design methods for synthetic biology |
| Abstract |
Computational protein design, a process that searches for mutants with desired improved properties, plays a central role in the conception of many synthetic biology devices including biosensors, bioproduction, or regulation circuits. To that end, a rational workflow for computational protein design is described here consisting of (a) searching in the sequence, structure or chemical spaces for the desired function and associated protein templates; (b) finding the list of potential hot regions to mutate in the parent proteins; and (c) performing in silico screening of mutants with predicted improved properties. |
| Apa Reference | Carbonell, P., & Trosset, J.-Y. (2014). Computational Protein Design Methods for Synthetic Biology. Computational Methods in Synthetic Biology, 3–21. 10.1007/978-1-4939-1878-2_1 |
| Doi | 10.1007/978-1-4939-1878-2_1 |
| Publication Date | 13 Nov 2014 |
| Publication Type | Book / chapter |
| Researcher | Pablo Carbonell |
| Ontology | Computational models and simulations, Mutation Analysis and design, Protein/Nucleic Acid design |
| Research Groups | Dynamics Biodesign Lab |
| Tools |