Detalle de: Role of Alanine Racemase Mutations in Mycobacterium tuberculosis D-Cycloserine Resistance
| Title | Role of Alanine Racemase Mutations in Mycobacterium tuberculosis D-Cycloserine Resistance |
| Abstract |
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d -cycloserine. |
| Apa Reference | Nakatani, Y., Opel-Reading, H. K., Merker, M., Machado, D., Andres, S., Kumar, S. S., Moradigaravand, D., Coll, F., Perdigão, J., Portugal, I., Schön, T., Nair, D., Devi, K. R. U., Kohl, T. A., Beckert, P., Clark, T. G., Maphalala, G., Khumalo, D., Diel, R., … Köser, C. U. (2017). Role of Alanine Racemase Mutations in Mycobacterium tuberculosis <scp>d</scp> -Cycloserine Resistance. Antimicrobial Agents and Chemotherapy, 61(12). 10.1128/aac.01575-17 |
| Doi | 10.1128/AAC.01575-17 |
| Publication Date | Dec 2017 |
| Publication Type | Article |
| Researcher | Francesc Coll I Cerezo |
| Ontology | Molecular evolution |
| Research Groups | Applied Microbial Genomics |
| Tools |