Detalle de: Rational design of a cyclin A fluorescent peptide sensor
| Title | Rational design of a cyclin A fluorescent peptide sensor |
| Abstract |
We report the design and development of a fluorescent sensor specifically designed to target cyclin A, a protein that plays a key role in the regulation of the cell cycle. Computational studies provide a molecular picture that explains the observed emission increase, suggesting that the 4-DMAP fluorophore in the peptide is protected from the bulk solvent when inserted into the hydrophobic binding groove of cyclin A. |
| Apa Reference | Pazos, E., Pérez, M., Gutiérrez-de-Terán, H., Orzáez, M., Guevara, T., Mascareñas, J. L., & Vázquez, M. E. (2011). Rational design of a cyclin A fluorescent peptide sensor. Organic & Biomolecular Chemistry, 9(22), 7629. 10.1039/c1ob06009k |
| Doi | 10.1039/c1ob06009k |
| Publication Date | 2011 |
| Publication Type | Article |
| Researcher | Hugo Gutiérrez de Terán Castañón |
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