Detalle de: A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases
| Title | A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases |
| Abstract |
(E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aβ and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aβ self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test). |
| Apa Reference | Staderini, M., Aulić, S., Bartolini, M., Tran, H. N. A., González-Ruiz, V., Pérez, D. I., Cabezas, N., Martínez, A., Martín, M. A., Andrisano, V., Legname, G., Menéndez, J. C., & Bolognesi, M. L. (2013). A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases. ACS Medicinal Chemistry Letters, 4(2), 225–229. 10.1021/ml3003605 |
| Doi | 10.1021/ml3003605 |
| Publication Date | 3 Jan 2013 |
| Publication Type | Article |
| Researcher | Ana Martínez |
| Ontology | Drug Discovery and design |
| Research Groups | Translational Medicinal and Biological Chemistry |
| Tools |