Detalle de: Thienyl and phenyl alpha-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching
| Title | Thienyl and phenyl alpha-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching |
| Abstract |
Glycogen synthase kinase (GSK-3beta) plays a crucial role in Alzheimer's disease (AD). Its inhibition is a valid approach to the treatment of AD. In this initial letter, some thienyl and phenyl alpha-halomethyl ketones are described as new non-ATP competitive inhibitors of GSK-3beta. They are considered as lead compounds for designing and synthesizing new series, to carry out SAR studies, clear up the mechanism of action, and, in general, evaluate their therapeutical usefulness. |
| Apa Reference | Conde, S., Pérez, D. I., Martínez, A., Perez, C., & Moreno, F. J. (2003). Thienyl and Phenyl α-Halomethyl Ketones: New Inhibitors of Glycogen Synthase Kinase (GSK-3β) from a Library of Compound Searching. Journal of Medicinal Chemistry, 46(22), 4631–4633. 10.1021/jm034108b |
| Doi | 10.1021/jm034108b |
| Publication Date | 20 Sep 2003 |
| Publication Type | Article |
| Researcher | Ana Martínez |
| Ontology | Structure-function relationship, Drug Discovery and design |
| Research Groups | Translational Medicinal and Biological Chemistry |
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