Detalle de: O-Pyrazolylpropynyl-Hydroxylamines as Versatile Intermediates in the Synthesis of Compounds of Pharmacological Interest
| Title | O-Pyrazolylpropynyl-Hydroxylamines as Versatile Intermediates in the Synthesis of Compounds of Pharmacological Interest |
| Abstract |
Through an optimised Pd/Cu-catalysed cross-coupling reaction of 4-iodopyrazoles with 2-propyn-1-ol, followed by Mitsunobu transformation with N-hydroxyphthalimide and subsequent hydrazinolysis, O-[(pyrazol-4-yl)-prop-2-ynyl]-hydroxylamines were obtained in good yields. Their usefulness as intermediates in the synthesis of pharmaceuticals is exemplified by the first reported intramolecular cyclization of O-(2-propynyl)-hydroxylamines to yield 4,5-dihydro-isoxazoles. |
| Apa Reference | Rodríguez-Franco, M. I., Dorronsoro, I., & Martínez, A. (2001). O-Pyrazolylpropynyl-Hydroxylamines as Versatile Intermediates in the Synthesis of Compounds of Pharmacological Interest. Synthesis, 2001(11), 1711–1715. 10.1055/s-2001-16768 |
| Doi | 10.1055/S-2001-16768 |
| Publication Date | 2001 |
| Publication Type | Article |
| Researcher | Ana Martínez |
| Ontology | |
| Research Groups | Translational Medicinal and Biological Chemistry |
| Tools |