Detalle de: Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity
| Title | Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity |
| Abstract |
The synthesis of acyclonucleosides derived from thieno[3,2-c] and thieno[2,3-c][1,2,6]thiadiazine 2,2-dioxides was achieved following the silylation method. Lipase-mediated methodology was employed for deprotection of the acyclic moieties. The antiviral effects were determined against a broad spectrum of viruses, including cytomegalovirus (CMV) and varicella zoster virus (VZV). Only minor antiviral activity against VZV was observed for those acyclonucleosides carrying a benzyl group. |
| Apa Reference | Martinez, A., Esteban, A., Gil, C., Conde, S., Andrei, G., Snoeck, R., Balzarini, J., & De Clercq, E. (2000). Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity. Antiviral Chemistry and Chemotherapy, 11(3), 221–230. 10.1177/095632020001100305 |
| Doi | 10.1177/095632020001100305 |
| Publication Date | Jun 2000 |
| Publication Type | Article |
| Researcher | Ana Martínez |
| Ontology | |
| Research Groups | Translational Medicinal and Biological Chemistry |
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