Detalle de: Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds
| Title | Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds |
| Abstract |
A 4-centre PDE4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured. |
| Apa Reference | Segarra, V., Isabel Crespo, M., Pujol, F., Beleta, J., Doménech, T., Miralpeix, M., Palacios, J. M., Castro, A., & Martinez, A. (1998). Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds. Bioorganic & Medicinal Chemistry Letters, 8(5), 505–510. 10.1016/s0960-894x(98)00058-4 |
| Doi | 10.1016/S0960-894X(98)00058-4 |
| Publication Date | Mar 1998 |
| Publication Type | Article |
| Researcher | Ana Martínez |
| Ontology | Biological Databases, Drug Discovery and design |
| Research Groups | Translational Medicinal and Biological Chemistry |
| Tools |