Detalle de: Near-atomic cryo-EM structure of PRC1 bound to the microtubule
| Title | Near-atomic cryo-EM structure of PRC1 bound to the microtubule |
| Abstract |
Significance PRC1 (protein regulator of cytokinesis 1) is critical to cellular architecture through its interaction with microtubules to form antiparallel microtubule arrays, like those in the spindle midzone. Here, cryo-EM studies describe, in close to atomic detail, the interaction of PRC1 with the microtubule surface. Together with previous studies, our structure leads to a model of how PRC1 promotes the establishment of stable, higher-order microtubule arrays. |
| Apa Reference | Kellogg, E. H., Howes, S., Ti, S.-C., Ramírez-Aportela, E., Kapoor, T. M., Chacón, P., & Nogales, E. (2016). Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Proceedings of the National Academy of Sciences, 113(34), 9430–9439. 10.1073/pnas.1609903113 |
| Doi | 10.1073/pnas.1609903113 |
| Publication Date | 4 Aug 2016 |
| Publication Type | Article |
| Researcher | Pablo Chacón |
| Ontology | Structural bioinformatics, Experimental structure determination |
| Research Groups | Structural Bioinformatics |
| Tools |