Detalle de: Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
| Title | Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc |
| Abstract |
Significance Here we report the structural bases of the interaction between the catalytic light subunit and the heavy subunit of the heteromeric amino acid transporters. Our data show that the large ectodomain of the human heavy subunit 4F2hc plays a key role in the interaction and stability of the light subunit L-type amino acid transporter 2. This finding paves the way for structural and functional studies to elucidate the role of the heavy subunit in the regulation of these transporters; such studies will be highly relevant in human pathology. |
| Apa Reference | Rosell, A., Meury, M., Álvarez-Marimon, E., Costa, M., Pérez-Cano, L., Zorzano, A., Fernández-Recio, J., Palacín, M., & Fotiadis, D. (2014). Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc. Proceedings of the National Academy of Sciences, 111(8), 2966–2971. 10.1073/pnas.1323779111 |
| Doi | 10.1073/pnas.1323779111 |
| Publication Date | 10 Feb 2014 |
| Publication Type | Article |
| Researcher | Juan Fernández Recio |
| Ontology | |
| Research Groups | Structural Bioinformatics, Modeling and Biological Mechanisms |
| Tools |