Detalle de: Neutrophils as indicators of obesity‐associated inflammation: A systematic review and meta‐analysis

Summary Introduction The aim of this study is to evaluate and compare the suitability of routine blood neutrophil values as indicators of obesity‐associated inflammation. Methods In this systematic review and meta‐analysis, we assess absolute neutrophil counts (ANCs) and neutrophil‐to‐lymphocyte ratio (NLR) values in subjects with and without obesity and analyze the weight of both parameters on the disease. Additionally, correlation studies between ANC and NLR with BMI, a parameter internationally accepted to define obesity are performed. Results Quantitative data from 12 (ANC) and 11 (NLR) studies were included, with a total of 4475 participants. The meta‐analysis shows that while both parameters are increased in the obesity group, ANC values present higher differences with the control and less heterogeneity among studies. Additionally, unlike NLR, ANC demonstrates a positive and significant correlation with BMI. Conclusion Overall, this meta‐analysis demonstrates that ANC is a more reliable and stable parameter than NLR for the assessment of obesity‐related inflammation, which offers clinicians a novel tool to assist in preventing complications related to obesity.