Detalle de: PP025—Improving hy’s law definition to better predict the risk of developing acute liver failure in drug-induced liver injury (DILI)
| Title | PP025—Improving hy’s law definition to better predict the risk of developing acute liver failure in drug-induced liver injury (DILI) |
| Abstract |
Prediction of serious DILI at early stages of drug development is a major concern. A broad “Hy’s Law” definition as ALT >3 × ULN and total bilirubin (TBL) >2 × ULN has been used to predict a worst DILI outcome. We aimed to examine the best way to define Hy’s law by analyzing whether the R value provides a better way of identifying hepatocellular (HC) versus cholestatic (Chol) contribution to injury at different time points, and whether an alkaline phosphatase (ALP) value above 2-fold indicates Chol predominance and low risk of acute liver failure/liver transplantation (ALF/OLT). |
| Apa Reference | Robles-Díaz, M., Stephens, C., Medina-Cáliz, I., González, A. F., González-Jiménez, A., Ulzurrun, E., Kaplowitz, N., Andrade, R. J., & Lucena, M. I. (2013). PP025—Improving hy’s law definition to better predict the risk of developing acute liver failure in drug-induced liver injury (DILI). Clinical Therapeutics, 35(8), e25. 10.1016/j.clinthera.2013.07.060 |
| Doi | 10.1016/j.clinthera.2013.07.060 |
| Publication Date | Aug 2013 |
| Publication Type | Article |
| Researcher | Andres Gonzalez-Jimenez |
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