Detalle de: The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin
| Title | The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin |
| Abstract |
The G6b gene, located in the human Major Histocompatibility Complex, encodes a receptor of the immunoglobulin (Ig) superfamily. In this study, we show using a variety of techniques that the extracellular domain of the G6b protein, containing a single Ig‐like domain, binds to heparin with high affinity. In an ELISA assay, this binding was displaceable with soluble heparin with an IC50 value of approximately 0.5 μg/ml. Other sulfated glycans showed weaker or no competition. The observed interaction between G6b and heparin is strongly salt dependent suggesting a mainly electrostatic interaction. Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand. |
| Apa Reference | de Vet, E.C., Newland, S.A., Lyons, P.A., Aguado, B. & Campbell, R.D. (2005). The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. FEBS Letters, 579(11), 2355-2358. 10.1016/j.febslet.2005.03.032 |
| Doi | 10.1016/j.febslet.2005.03.032 |
| Publication Date | 25 Mar 2005 |
| Publication Type | Article |
| Researcher | Begoña Aguado Orea † |
| Ontology | Molecular Interactions/Docking |
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