Detalle de: A reference map of the human binary protein interactome
| Title | A reference map of the human binary protein interactome |
| Abstract |
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships 1,2 . Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome 3 , transcriptome 4 and proteome 5 data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes. |
| Apa Reference | Luck, K., Kim, D., Lambourne, L., Spirohn, K., Begg, B.E., Bian, W., Brignall, R., Cafarelli, T., Campos-Laborie, F.J., Charloteaux, B., Choi, D., Coté, A.G., Daley, M., Deimling, S., Desbuleux, A., Dricot, A., Gebbia, M., Hardy, M.F., Kishore, N., Knapp, J.J., Kovács, I.A., Lemmens, I., Mee, M.W., Mellor, J.C., Pollis, C., Pons, C., Richardson, A.D., Schlabach, S., Teeking, B., Yadav, A., Babor, M., Balcha, D., Basha, O., Bowman-Colin, C., Chin, S., Choi, S.G., Colabella, C., Coppin, G., D’Amata, C., De Ridder, D., De Rouck, S., Duran-Frigola, M., Ennajdaoui, H., Goebels, F., Goehring, L., Gopal, A., Haddad, G., Hatchi, E., Helmy, M., Jacob, Y., Kassa, Y., Landini, S., Li, R., van Lieshout, N., MacWilliams, A., Markey, D., Paulson, J.N., Rangarajan, S., Rasla, J., Rayhan, A., Rolland, T., San-Miguel, A., Shen, Y., Sheykhkarimli, D., Sheynkman, G.M., Simonovsky, E., Taşan, M., Tejeda, A., Tropepe, V., Twizere, J., Wang, Y., Weatheritt, R.J., Weile, J., Xia, Y., Yang, X., Yeger-Lotem, E., Zhong, Q., Aloy, P., Bader, G.D., De Las Rivas, J., Gaudet, S., Hao, T., Rak, J., Tavernier, J., Hill, D.E., Vidal, M., Roth, F.P. & Calderwood, M.A. (2020). A reference map of the human binary protein interactome. Nature, 580(7803), 402-408. 10.1038/s41586-020-2188-x |
| Doi | 10.1038/s41586-020-2188-x |
| Publication Date | 8 Apr 2020 |
| Publication Type | Article |
| Researcher | Javier De Las Rivas |
| Ontology | Transcriptomics, Genomics, Proteomics, Protein-Protein Interactions |
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