Detalle de: VP3.15 TREATMENT IMPROVES BRAIN ATROPHY AND PROMOTES NEUROREGENERATION IN A MURINE MODEL OF GERMINAL MATRIX-INTRAVENTRICULAR HEMORRHAGE OF THE PRETERM NEWBORN
| Title | VP3.15 TREATMENT IMPROVES BRAIN ATROPHY AND PROMOTES NEUROREGENERATION IN A MURINE MODEL OF GERMINAL MATRIX-INTRAVENTRICULAR HEMORRHAGE OF THE PRETERM NEWBORN |
| Abstract |
Germinal matrix intraventricular hemorrhage (GM-IVH) is one of the most severe neuropathological complications associated with prematurity and it has no successful treatment. Preterm newborns (PT) that suffer GM-IVH commonly develop short and long-term motor, cognitive and behavioral impairments. Previous studies have shown the neuroprotective role of the dual glycogen synthase kinase 3β and phosphodiesterase inhibitor, VP3.15, in other neurodegenerative and neurodevelopmental disorders. Therefore, we have analyzed the effects of treatment with VP3.15 in a murine model of GM-IVH that mimics brain pathology and cognitive impairment observed in patients. |
| Apa Reference | Navarro, I.A., Del Marco, A., Benavente-Fernandez, I., Segado-Arenas, A., Carmen, G., Martinez, A., Lubian-Lopez, S. & Garcia-Alloza, M. (2023). VP3.15 TREATMENT IMPROVES BRAIN ATROPHY AND PROMOTES NEUROREGENERATION IN A MURINE MODEL OF GERMINAL MATRIX-INTRAVENTRICULAR HEMORRHAGE OF THE PRETERM NEWBORN. IBRO Neuroscience Reports, 15, S362-S363. 10.1016/j.ibneur.2023.08.683 |
| Doi | 10.1016/j.ibneur.2023.08.683 |
| Publication Date | Oct 2023 |
| Publication Type | Article |
| Researcher | Ana Martínez |
| Ontology | Drug Discovery and design |
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