Detalle de: Application of experimental design methodology to the study of the synthesis of nucleosides

A factorial design has been used to study the effect of three factors on the reaction between 4‐amino‐8 H ‐pyrazino[2,3‐ c ]‐1,2,6‐thiadiazine 2,2‐dioxide and 1,2,3,5‐tetra‐ O ‐acetyl‐β‐D‐ribofuranose. Reaction conditions have been found in which the usually less abundant N‐8 isomer is selectively obtained.