Detalle de: Principal component analysis is limited to low-resolution analysis in cryoEM
| Title | Principal component analysis is limited to low-resolution analysis in cryoEM |
| Abstract |
Principal component analysis (PCA) has been widely proposed to analyze flexibility and heterogeneity in cryo-electron microscopy (cryoEM). In this paper, it is argued that (i) PCA is an excellent technique to describe continuous flexibility at low resolution (but not so much at high resolution) and (ii) PCA components should be analyzed in a concerted manner (and not independently). |
| Apa Reference | Sorzano, C.O.S. & Carazo, J.M. (2021). Principal component analysis is limited to low-resolution analysis in cryoEM. Acta Crystallographica Section D Structural Biology, 77(6), 835-839. 10.1107/s2059798321002291 |
| Doi | 10.1107/s2059798321002291 |
| Publication Date | 19 May 2021 |
| Publication Type | Article |
| Researcher | Jose María Salvador Carazo Garcia |
| Ontology | Experimental structure determination, Molecular flexibility, Multivariate statistics, Cryo-electron microscopy, Dimensionality reduction |
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