Detalle de: MICROGLIA REGULATE LEARNING AND MEMORY THROUGH NF-ΚB
| Title | MICROGLIA REGULATE LEARNING AND MEMORY THROUGH NF-ΚB |
| Abstract |
Microglia, the resident immune cells of the CNS, have been implicated in brain plasticity and function. However, the mechanisms remain largely unknown. Here, we show that Cre-dependent removal of the RelA subunit of the NF-κB transcription factor from adult microglia results in impaired learning and synaptic plasticity. Depletion of RelA in microglia elicits changes in chromatin accessibility and transcriptome landscapes of microglia associated with specific gene regulatory programs driving the activation of specific microglia phenotypes. |
| Apa Reference | Bhojwani-Cabrera, A.M., Navarrón-Izquierdo, C.M., Márquez-Galera, Á., Royo, M., Niñerola, S., Expósito-Coca, M.A., López-López, V., Medrano-Relinque, J., Gruart, A., Barco, A., Jurado, S., Delgado-García, J.M. & López-Atalaya, J.P. (2023). MICROGLIA REGULATE LEARNING AND MEMORY THROUGH NF-ΚB. IBRO Neuroscience Reports, 15, S270-S271. 10.1016/j.ibneur.2023.08.468 |
| Doi | 10.1016/j.ibneur.2023.08.468 |
| Publication Date | Oct 2023 |
| Publication Type | Article |
| Researcher | Jose P. López-Atalaya Martínez |
| Ontology | Transcriptomics, Epigenomics, Regulatory biology, Chromatin accessibility |
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