Detalle de: Identification of the first structurally validated covalent ligands of the small GTPase RAB27A
| Title | Identification of the first structurally validated covalent ligands of the small GTPase RAB27A |
| Abstract |
A novel Rab27A construct enables elucidation of covalent ligand binding, paving the way for structure-guided approaches against this challenging target. |
| Apa Reference | Jamshidiha, M., Lanyon-Hogg, T., Sutherell, C.L., Craven, G.B., Tersa, M., De Vita, E., Brustur, D., Pérez-Dorado, I., Hassan, S., Petracca, R., Morgan, R.M., Sanz-Hernández, M., Norman, J.C., Armstrong, A., Mann, D.J., Cota, E. & Tate, E.W. (2022). Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. RSC Medicinal Chemistry, 13(2), 150-155. 10.1039/d1md00225b |
| Doi | 10.1039/d1md00225b |
| Publication Date | 2022 |
| Publication Type | Article |
| Researcher | Juana Inmaculada Pérez Dorado |
| Ontology | Molecular Interactions/Docking |
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