Detalle de: Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors
| Title | Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors |
| Abstract |
In a search for structurally new inhibitors of fructose-1,6-bisphosphatase (F16BPase), substituted 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives were synthesized. It has been shown that the 2,3-dihydro-1H-cyclopenta[b]quinoline moiety may represent a suitable scaffold for the synthesis of potent F16BPase inhibitors endowed with significantly lower EGFR tyrosine kinase inhibitory activity. |
| Apa Reference | Rosini, M., Mancini, F., Tarozzi, A., Colizzi, F., Andrisano, V., Bolognesi, M.L., Hrelia, P. & Melchiorre, C. (2006). Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors. Bioorganic & Medicinal Chemistry, 14(23), 7846-7853. 10.1016/j.bmc.2006.07.059 |
| Doi | 10.1016/j.bmc.2006.07.059 |
| Publication Date | Dec 2006 |
| Publication Type | Article |
| Researcher | Francesco Colizzi |
| Ontology | Genome Assembly, Drug Discovery and design |
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