Detalle de: Common Ancestry of the CENP-A Chaperones Scm3 and HJURP
| Title | Common Ancestry of the CENP-A Chaperones Scm3 and HJURP |
| Abstract |
The centromere is a unique chromosomal locus that ensures accurate segregation of chromosomes during cell division. The centromere supports assembly of a multiprotein complex called the kinetochore, which attaches to spindle microtubules. The kinetochore has specialized nucleosomes in which histone H3 is replaced by the centromere-specific H3 variant CENP-A/cenH3 (reviewed in Allshire and Karpen, 2008). Two recent papers in Cell (Dunleavy et al., 2009; Foltz et al., 2009) have identified a new protein partner for soluble human CENP-A called HJURP/hFLEG/FAKTS that promotes the incorporation of CENP-A at centromeres. |
| Apa Reference | Sanchez-Pulido, L., Pidoux, A.L., Ponting, C.P. & Allshire, R.C. (2009). Common Ancestry of the CENP-A Chaperones Scm3 and HJURP. Cell, 137(7), 1173-1174. 10.1016/j.cell.2009.06.010 |
| Doi | 10.1016/j.cell.2009.06.010 |
| Publication Date | Jun 2009 |
| Publication Type | Article |
| Researcher | Luis Francisco Sánchez Pulido |
| Ontology | Histone structure and regulation |
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