Detalle de: CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease
| Title | CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease |
| Abstract |
Altered CPEBs and mRNA polyadenylation lead to thiamine deficiency in the brains of patients and mice with Huntington’s disease. |
| Apa Reference | Picó, S., Parras, A., Santos-Galindo, M., Pose-Utrilla, J., Castro, M., Fraga, E., Hernández, I.H., Elorza, A., Anta, H., Wang, N., Martí-Sánchez, L., Belloc, E., Garcia-Esparcia, P., Garrido, J.J., Ferrer, I., Macías-García, D., Mir, P., Artuch, R., Pérez, B., Hernández, F., Navarro, P., López-Sendón, J.L., Iglesias, T., Yang, X.W., Méndez, R. & Lucas, J.J. (2021). CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease. Science Translational Medicine, 13(613). 10.1126/scitranslmed.abe7104 |
| Doi | 10.1126/scitranslmed.abe7104 |
| Publication Date | 29 Sep 2021 |
| Publication Type | Article |
| Researcher | María Santos Galindo |
| Ontology | Transcriptomics |
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