Detalle de: Rational design of a Tn antigen mimic
| Title | Rational design of a Tn antigen mimic |
| Abstract |
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies. |
| Apa Reference | Corzana, F., Busto, J.H., Marcelo, F., García de Luis, M., Asensio, J.L., Martín-Santamaría, S., Sáenz, Y., Torres, C., Jiménez-Barbero, J., Avenoza, A. & Peregrina, J.M. (2011). Rational design of a Tn antigen mimic. Chemical Communications, 47(18), 5319. 10.1039/c1cc10192g |
| Doi | 10.1039/c1cc10192g |
| Publication Date | 2011 |
| Publication Type | Article |
| Researcher | Sonsoles Martin Santamaría |
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