Detalle de: Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities
| Title | Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities |
| Abstract |
Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies. |
| Apa Reference | Julián, M., Cacho, M., García, M.A., Martín-Santamaría, S., de Pascual-Teresa, B., Ramos, A., Martínez, A. & Cuttitta, F. (2005). Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities. European Journal of Medicinal Chemistry, 40(8), 737-750. 10.1016/j.ejmech.2004.10.016 |
| Doi | 10.1016/j.ejmech.2004.10.016 |
| Publication Date | Aug 2005 |
| Publication Type | Article |
| Researcher | Sonsoles Martin Santamaría |
| Ontology | Drug Discovery and design |
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