Detalle de: Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives
| Title | Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives |
| Abstract |
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4-0.5 μM are able to show in vivo activity. |
| Apa Reference | Chaparro, M.J., Vidal, J., Angulo-Barturen, Í., Bueno, J.M., Burrows, J., Cammack, N., Castañeda, P., Colmenarejo, G., Coterón, J.M., de las Heras, L., Fernández, E., Ferrer, S., Gabarró, R., Gamo, F.J., García, M., Jiménez-Díaz, M.B., Lafuente, M.J., León, M.L., Martínez, M.S., Minick, D., Prats, S., Puente, M., Rueda, L., Sandoval, E., Santos-Villarejo, Á., Witty, M. & Calderón, F. (2014). Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives. ACS Medicinal Chemistry Letters, 5(6), 657-661. 10.1021/ml500015r |
| Doi | 10.1021/ml500015r |
| Publication Date | 26 Mar 2014 |
| Publication Type | Article |
| Researcher | Gonzalo Colmenarejo |
| Ontology | Drug Discovery and design |
| Research Groups | |
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