Detalle de: Exploiting tertiary structure through local folds for crystallographic phasing
| Title | Exploiting tertiary structure through local folds for crystallographic phasing |
| Abstract |
We describe an algorithm for phasing protein crystal X-ray diffraction data that identifies, retrieves, refines and exploits general tertiary structural information from small fragments available in the Protein Data Bank. The algorithm successfully phased, through unspecific molecular replacement combined with density modification, all-helical, mixed alpha-beta, and all-beta protein structures. The method is available as a software implementation: Borges. |
| Apa Reference | Sammito, M., Millán, C., Rodríguez, D.D., de Ilarduya, I.M., Meindl, K., De Marino, I., Petrillo, G., Buey, R.M., de Pereda, J.M., Zeth, K., Sheldrick, G.M. & Usón, I. (2013). Exploiting tertiary structure through local folds for crystallographic phasing. Nature Methods, 10(11), 1099-1101. 10.1038/nmeth.2644 |
| Doi | 10.1038/nmeth.2644 |
| Publication Date | 15 Sep 2013 |
| Publication Type | Software |
| Researcher | Isabel Uson Finkenzeller |
| Ontology | Bioinformatics Software and Tools, Structural bioinformatics, Experimental structure determination |
| Research Groups | |
| Tools | ARCIMBOLDO |