Research Group

Detalle de: Fungal Biofactories

Title	Fungal Biofactories
Description	Fungal biofactories; Filamentous fungi; Yeasts; Synthetic biology; Genome editing; Antifungals; Protein and enzyme bioproduction; Bioactive molecules; Metabolic engineering; Plant biomass valorization
Home Page	https://www.iata.csic.es/en/research/fungal-biofactories
Contact Email	jmarcos@csic.es
Collaborating Companies
Spin Off
Patents
Hpc Resources
Institution	IATA
Ontology	Genomics, Genome editing (CRISPR)
Tools
Service Units
Research Lines	Synthetic biology and genome editing of filamentous fungi and yeasts, Fungal bioproduction of proteins, enzymes and bioactive molecules
Funded Projects	Knowledge-based design and discovery of new antifungal proteins as sustainable biofungicides (SmartAFP)
Selected Publications	Comparative metabolomic analysis of the phloem sap of nine citrus relatives with different degrees of susceptibility to Huanglongbing disease Article · 28 Jun 2024 Novel findings about the mode of action of the antifungal protein PeAfpA against Saccharomyces cerevisiae Article · 9 Sep 2023 Transcriptomic Profile of Penicillium digitatum Reveals Novel Aspects of the Mode of Action of the Antifungal Protein AfpB Article · 15 Jun 2023 Application of recyclable CRISPR/Cas9 tools for targeted genome editing in the postharvest pathogenic fungi Penicillium digitatum and Penicillium expansum Article · 17 Mar 2022 Development of a FungalBraid Penicillium expansum‐based expression system for the production of antifungal proteins in fungal biofactories Article · 27 Jan 2022 View all (57 more) Antifungal Peptides and Proteins to Control Toxigenic Fungi and Mycotoxin Biosynthesis Article · 9 Dec 2021 Potential of Antifungal Proteins (AFPs) to Control Penicillium Postharvest Fruit Decay Article · 4 Jun 2021 A Novel Secreted Cysteine-Rich Anionic (Sca) Protein from the Citrus Postharvest Pathogen Penicillium digitatum Enhances Virulence and Modulates the Activity of the Antifungal Protein B (AfpB) Article · 2 Oct 2020 The antifungal protein afpb induces regulated cell death in its parental fungus penicillium digitatum Article · 26 Aug 2020 The Penicillium chrysogenum Q176 Antimicrobial Protein PAFC Effectively Inhibits the Growth of the Opportunistic Human Pathogen Candida albicans Article · 19 Aug 2020 Calcium homeostasis plays important roles in the internalization and activities of the small synthetic antifungal peptide PAF26 Article · 17 Jun 2020 Multigene Engineering by GoldenBraid Cloning: From Plants to Filamentous Fungi and Beyond Article · Mar 2020 Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies Article · 22 Oct 2019 The myosin motor domain-containing chitin synthases are involved in cell wall integrity and sensitivity to antifungal proteins in penicillium digitatum Article · 18 Oct 2019 Rice seeds as biofactories of rationally designed and cell-penetrating antifungal PAF peptides Article · 7 Jun 2019 Efficient production of antifungal proteins in plants using a new transient expression vector derived from tobacco mosaic virus Article · 6 Dec 2018 Rational design and biotechnological production of novel afpb-paf26 chimeric antifungal proteins Article · 15 Oct 2018 Three antifungal proteins from penicillium expansum: Different patterns of production and antifungal activity Article · 5 Oct 2018 Tryptophan-containing dual neuroprotective peptides: Prolyl endopeptidase inhibition and caenorhabditis elegans protection from β-amyloid peptide toxicity Article · 16 May 2018 Efficient production and characterization of the novel and highly active antifungal protein AfpB from Penicillium digitatum Article · 7 Nov 2017 Effect of Trichoderma-enriched organic charcoal in the integrated wood protection strategy Article · 10 Aug 2017 Mapping and identification of antifungal peptides in the putative antifungal protein AfpB from the filamentous fungus Penicillium digitatum Article · 6 Apr 2017 A Penicillium chrysogenum-based expression system for the production of small, cysteine-rich antifungal proteins for structural and functional analyses Article · 11 Nov 2016 Nitric oxide in fungi: is there NO light at the end of the tunnel? Article · 17 Feb 2016 Occurrence and function of fungal antifungal proteins: a case study of the citrus postharvest pathogen Penicillium digitatum Article · 7 Nov 2015 Nitric oxide synthesis by nitrate reductase is regulated during development in Aspergillus Article · 14 Oct 2015 Concatemerization increases the inhibitory activity of short, cell-penetrating, cationic and tryptophan-rich antifungal peptides Article · 7 Apr 2015 The Penicillium digitatum protein O-mannosyltransferase Pmt2 is required for cell wall integrity, conidiogenesis, virulence and sensitivity to the antifungal peptide PAF26 Article · 4 Feb 2015 FLO11 gene is involved in the interaction of flor strains of saccharomyces cerevisiae with a biofilm-promoting synthetic hexapeptide Article · Oct 2013 Two Functional Motifs Define the Interaction, Internalization and Toxicity of the Cell-Penetrating Antifungal Peptide PAF26 on Fungal Cells Article · 21 Jan 2013 Concentration-dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26 Article · 31 May 2012 Antifungal peptides: Exploiting non-lytic mechanisms and cell penetration properties Book / chapter · Jan 2012 Antimicrobial Peptides Other · 22 Nov 2011 A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides Article · 15 Nov 2010 Antihypertensive properties of lactoferricin B-derived peptides Article · 6 May 2010 β-Glucanases as a tool for the control of wine spoilage yeasts Article · Jan 2010 A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection Article · 2010 Antimicrobial peptides: To membranes and beyond Article · 21 May 2009 Comparative study of antimicrobial peptides to control citrus postharvest decay caused by Penicillium digitatum Article · 15 Sep 2007 High-throughput approaches to the identification of citrus genes involved in fruit response to penicillium digitatum infection Article · Mar 2007 Activity and mode of action against fungal phytopathogens of bovine lactoferricin-derived peptides Article · Dec 2006 Studies on the mode of action of the antifungal hexapeptide PAF26 Article · Nov 2006 Lactoferricin-related peptides with inhibitory effects on ACE-dependent vasoconstriction Article · 23 Jun 2006 Transient structural ordering of the RNA-binding domain of carnation mottle virus p7 movement protein modulates nucleic acid binding Article · 5 Aug 2005 Biochemical and molecular analysis of carotenoid biosynthesis in flavedo of orange (Citrus sinensis L.) during fruit development and maturation Article · 5 Oct 2004 Characterization of Pinalate, a novel Citrus sinensis mutant with a fruit-specific alteration that results in yellow pigmentation and decreased ABA content Article · 1 Feb 2003 Complexation of imazalil with β-cyclodextrin, residue uptake, persistence, and activity against Penicillium decay in citrus fruit following postharvest dip treatments Article · 2 Oct 2002 Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library Article · May 2002 Identification of a peptide with specific activity against fungi that cause postharvest decay in fruits Article · Jun 2001 Molecular characterization of an almond isolate of hop stunt viroid (HSVd) and conditions for eliminating spurious hybridization in its diagnosis in almond samples Article · Sep 1999 Characterization and in vitro translation analysis of pelargonium flower break virus Article · Aug 1999 Studies on the incidence of hop stunt viroid in apricot trees (Prunus armeniaca) by using an easy and short extraction method to analyze a large number of samples Article · Nov 1998 Simultaneous accumulation of multiple viral coat proteins from a TEV-NIa based expression vector Article · Jan 1998 Carmovirus isolation and RNA extraction. Book / chapter · 1998 Hop stunt viroid (HSVd) sequence variants from Prunes species: Evidence for recombination between HSVd isolates Article · 1 Dec 1997 Transgenic accumulation of two plant virus coat proteins on a single self processing polypeptide Article · 1 Jul 1997 Studies on the diagnosis of hop stunt viroid in fruit trees: Identification of new hosts and application of a nucleic acid extraction procedure based on non-organic solvents Article · Nov 1996 The complete nucleotide sequence of yam mosaic virus (Ivory Coast isolate) genomic RNA Article · Jul 1996 Inhibition of a plant virus infection by analogs of melittin Article · 19 Dec 1995 Replication of avocado sunblotch viroid: Evidence for a symmetric pathway with two rolling circles and hammerhead ribozyme processing Article · 20 Dec 1994 In vitro characterization of a cassette to accumulate multiple proteins through synthesis of a self-processing polypeptide Article · Feb 1994 The 5' end generated in the in vitro self-cleavage reaction of avocado sunblotch viroid RNAs is present in naturally occurring linear viroid molecules Article · 1 May 1993
Researchers	Jose F. Marcos

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