Detalle de: Mechanisms of Neuronal Maintenance

We investigate the role of non-neuronal cells in brain physiology and pathology. Our recent studies focus on the activity of microglia and endothelial cells, having described the relevant role of hypoxia and angiogenesis signaling pathways in the pathology of Alzheimer's disease (AD). In particular, we have described a new mechanism by which blood vessels are altered during the course of the disease, causing hypoxia and nutrient stress in microglial cells. The description of vascular scars –VaS– represents a new histopathological finding in AD models and open a new vascular hypothesis that could contribute to disease progression, the non-productive angiogenesis.