SSCPE
The framework SSCPE.pl infers Maximum Likelihood (ML) phylogenetic trees adoping the Structure and Stability constrained model of protein evolution (SSCPE) [1] that predicts site-specific selective pressures by fitting only two global parameters for the whole protein: the selection strength Lambda_str for maintaining protein structure and Lambda_stab for maintaining the protein folding stability against unfolding and misfolding [5,6].
Basic Information
| Repository | https://github.com/ugobas/SSCPE |
| Documentation | https://github.com/ugobas/SSCPE |
| Seminar | Ugo Bastolla presents the tools TNM, PC_ali & SSCPE |
| Main publication (DOI) | 10.1101/2023.01.22.525075 |
| Contact email | ubastolla@cbm.csic.es |
| Authors/Maintainers | Ugo Bastolla |
| Type of application | Package for compiling the executable program |
| Programming languages | CPerl |
| Keywords | Computational Methods, Molecular evolution, Phylogenetic Analysis, Evolutionary rates |
Technical details
| Input file formats | fasta, pdb |
| Output file formats | Other |
| Software compatibility | Linux |
| Hardware requirements | Any linux computer |
| Type of containerization | None |
| Wrapper type | None |
| Compatible tools | RAxML-NG for maximum likelihood phylogenetic inference |
| Funding resource | National competitive funding |
| Funding support | No funding |
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| Citations (last 12 months) | <100 (~3 as of 15/10/2026) |
| Citations (since first release) | <100 (5 as of 15/10/2026) |
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