PROFILE
PROFILE is a tool designed to personalize patient-specific Boolean models using omics data. Boolean models are a type of mathematical model used to represent biological systems, where each element (e.g., a gene or protein) can exist in one of two states (e.g., on or off). PROFILE can be used to tailor Boolean models to reflect the unique characteristics of a patient's cellular biology by integrating patient-specific omics data into the Boolean model variables, enabling the creation of patient-specific intracellular models that reflect the biological characteristics of a patient's cells.
Basic Information
| Repository | https://github.com/ArnauMontagud/PROFILE_v2 |
| Documentation | https://github.com/ArnauMontagud/PROFILE_v2 |
| Seminar | Arnau Montagud presents the tool PROFILE |
| Main publication (DOI) | 10.3389/fphys.2018.01965 view |
| Contact email | arnau.montagud@csic.es |
| Authors/Maintainers | Arnau Montagud Aquino |
| Type of application | R/python package |
| Programming languages | PythonR |
| Keywords | Computational Methods, Applications of Computational Biology, Computational models and simulations, Biosystems Modeling, Gene regulatory networks, Personal medicine, Systems Biology, Integrative Analysis, Regulatory biology |
Technical details
| Input file formats | Other |
| Output file formats | csv |
| Software compatibility | Linux, Mac, Windows |
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| Type of containerization | Singularity/AppTainer |
| Wrapper type | Nextflow, Snakemake |
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| Funding resource | EU funding |
| Funding support | No funding |
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| Citations (last 12 months) | <100 (~10 as of 15/10/2026) |
| Citations (since first release) | <100 (83 as of 15/10/2026) |
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