ALEPH
A network-based bioinformatics tool for generating libraries for fragment-based molecular replacement and for structure interpretation. The geometrical description is based on vectors computed from the centroid of all Cα to the centroid of all carbonyl O in a polypeptide stretch, cast in a network to represent protein structure. Through its graphical interface (ALEPHUI) it offers annotation, decomposition, library generation and superposition. It is integrated in the ARCIMBOLDO framework.
Basic Information
| Repository | https://pypi.org/project/aleph/ |
| Documentation | http://chango.ibmb.csic.es/aleph.html |
| Main publication (DOI) | 10.1107/S2059798320001679 view |
| Contact email | alephbugs@gmail.com |
| Authors/Maintainers | Isabel Uson Finkenzeller |
| Type of application | R/python package, Desktop application |
| Programming languages | Python |
| Keywords | Structural bioinformatics, Experimental structure determination |
Technical details
| Input file formats | |
| Output file formats | |
| Software compatibility | Linux, Mac |
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Statistics
| Unique users (last 12 months) | |
| Unique users (since first release) | |
| Software downloads (last 12 months) | |
| Software downloads (since first release) | >10000 (77252 as of 15/10/2026) |
| Jobs submitted (last 12 months) | |
| Jobs submitted (since first release) | |
| Repository clones (last 12 months) | |
| Repository clones (since first release) | |
| Citations (last 12 months) | <100 (~1 as of 15/10/2026) |
| Citations (since first release) | <100 (16 as of 15/10/2026) |
| Early-stage researcher effort (development) | |
| Early-stage researcher effort (maintenance) | |
| Technician-supported effort (development) | |
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