Detalle de: System level analysis of the metabolic robustness in bacteria (RobDcode)

PI: Juan Nogales (CIB-CSIC and CNB-CSIC).

The understanding of the genotype-phenotype relationship is a fundamental biological question, widely studied, but still not understood in all its dimension. The existence of emergent systems properties largely hampers the linearity of this relationship making it mandatory the study of such properties to fully understand the biological systems. The robustness, understood as the property that allows the systems to maintain their functions despite external and internal perturbations, is a system-level phenomenon ubiquitously observed in living systems, however it is still poorly understood at molecular level. RobDcode was the foundational project of SBG and undertook the exploration of molecular mechanisms that confer robustness upon bacterial systems. This endeavour embraced an integrative approach spanning microbiological, molecular, and systems biology strategies. The outcomes of this project yielded significant insights, including the identification of robustness cycles. Contrary to being mere futile loops, these cycles were established to play a pivotal role in furnishing metabolic resilience to Pseudomonas putida amid various environmental disturbances.