Detalle de: Exercise and tumor proteome: Insights from a neuroblastoma model
| Title | Exercise and tumor proteome: Insights from a neuroblastoma model |
| Abstract |
We used liquid chromatography with tandem mass spectrometry to explore the impact of a 5-wk exercise intervention on the tumor proteome profile in a mouse model of one of the most aggressive childhood malignancies, high-risk neuroblastoma. Exercise altered the abundance of hundreds of proteins and pathways, particularly those involved in energy metabolism and tumor suppression. These molecular changes could mediate, at least partly, the potential antitumorigenic effects of exercise. |
| Apa Reference | Plaza-Florido, A., Gálvez, B. G., López, J. A., Santos-Lozano, A., Zazo, S., Rincón-Castanedo, C., Martín-Ruiz, A., Lumbreras, J., Terron-Camero, L. C., López-Soto, A., Andrés-León, E., González-Murillo, Á., Rojo, F., Ramírez, M., Lucia, A., & Fiuza-Luces, C. (2024). Exercise and tumor proteome: insights from a neuroblastoma model. Physiological Genomics, 56(12), 833–844. 10.1152/physiolgenomics.00064.2024 |
| Doi | 10.1152/physiolgenomics.00064.2024 |
| Publication Date | 1 Dec 2024 |
| Publication Type | Article |
| Researcher | Eduardo Andrés-León |
| Ontology | Model organisms, Proteomics |
| Research Groups | Computational Biomedicine and Health Data Science |
| Tools |