Eduardo Andrés-León
Biography
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I completed a degree and a PhD in Biological Sciences at the Universidad Autónoma de Madrid. I began my research career in the field of bioinformatics under the mentoring of Prof. Alfonso Valencia (H index 108, >67,000 citations), working at the Spanish National Centre for Biotechnology (CNB), the Spanish National Bioinformatics Institute (ISCIII-INB), and the Spanish National Cancer Research Centre (CNIO). In 2013, I joined the Institute of Biomedicine of Seville (IBIS) as head of the Bioinformatics Unit within the Computational Biology Group led by Dr. Ana M. Rojas (H index 31, >2,900 citations). Since 2015, I have been based at the Institute of Parasitology and Biomedicine “López-Neyra” (IPBLN), collaborating closely with Dr. Javier Martín (H index 79, >32,000 citations). In March 2025, I was appointed as a Tenured Scientist (Científico Titular) at the Spanish National Research Council (CSIC), in the specialty of “Applications of Artificial Intelligence in Life Sciences.” Over the past years, I have broadened my expertise into the areas of machine learning (ML), natural language processing (NLP), and deep learning, applying these approaches to complex biomedical data. Currently, I lead projects focused on the identification of biomarkers for complex diseases using ML methods, as well as the application of computer vision and deep learning for the analysis of medical images. These efforts support personalized medicine by facilitating diagnosis and treatment selection. My research career has also included the development of computational tools to explore non-coding genetic regulators in human disease. Notably, I have studied miRNA–mRNA interactions across multiple cancer types, linking them to patient survival, and extended this work to autoimmune, infectious, and neurological diseases. With over 70 scientific publications, I actively collaborate with numerous research groups, contributing to over 40 national and international research projects. I have supervised seven Master’s theses and frequently present at scientific conferences—receiving a best poster award—and contribute as a lecturer in Master’s programs, specialization diplomas, and summer courses at various Spanish universities and CSIC training initiatives. In addition to my research activities, I serve on the editorial board of a scientific journal, participate in organizing international symposiums, and regularly act as a reviewer for more than 30 journals (conducting ~35 reviews annually). I have also been a member of evaluation panels, including the Innova call from the Spanish Association for Cancer Research, focused on transferring research findings into clinical applications. I am also part of the IPBLN’s scientific dissemination unit, participating in outreach initiatives such as the European Researchers’ Night, student visits, and media engagement to communicate scientific findings to the public. With 20 years of experience in bioinformatics, I have developed independent and collaborative research lines in high-level institutions, working on large-scale projects with cutting-edge technologies, including single-cell “omics” for studying SARS-CoV-2. I remain deeply committed to scientific dissemination and translational research that bridges computational biology and biomedical innovation. |
Profile
| Institution | IPBLN |
| Position | Tenured Scientist (Científico Titular), Head of the Bioinformatics Unit |
| Home page | http://bioinfo.ipb.csic.es |
| Contact email | eduardo.andres@csic.es |
| ORCID | 0000-0002-0621-9914 |
BCB Hub
| BCB Committee | Expertise mapping, Talent attraction and training, Teaching links with University |
| BCB Tools | miARma-Seq, miRGate, reanalyzerGSE |
| BCB Services | Computational Biology and Bioinformatics Unit at IPBLN |
Research
Research topics
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Research lines
Projects, networks, transfer & teaching
Teaching
Master programs
- Advanced Master on Bioinformatics - Universidad Pablo de Olavide (BCB coordinator)
- Master on Clinical Bioinformatics - CNIC
- Expert Diploma in Bioinformatics and Data Analysis - Universidad Pablo de Olavide
- MSc in Bioinformatics and Computational Biology - Universidad Autónoma de Madrid - https://uam.es/CentroEstudiosPosgrado/MU_Bioinformatica_Y_Biologia_Computacional/1446787799364.htm (BCB coordinator)
- MSc in Bioinformatics and Data Science in Personalised Medicine and Health - Instituto de Salud Carlos III - https://masterbioinformatica.com/ (BCB coordinator)
- MSc in Omics Data Analysis and Systems Biology - Universidad de Sevilla and Universidad Internacional de Andalucía - https://www.us.es/estudiar/que-estudiar/oferta-de-masteres/master-universitario-en-analisis-de-datos-omicos-y https://www.unia.es/estudios-y-acceso/oferta-academica/masteres-oficiales/master-universitario-en-analisis-de-datos-omicos-y-biologia-de-sistemas (BCB coordinator)
Funded projects 2
Publications 101 entries
- Circular RNA-associated QTLs show stronger association with splicing-QTLs than with expression-QTLs Preprint · 29 May 2026
- Sex-biased Fibroblast Subpopulations and Transcriptional Programs Reveal Mechanisms of Skin Lesion Development in Systemic Sclerosis Preprint · 9 May 2026
- Selective cross-TAD gene regulation by the Tcra enhancer during T cell development Preprint · 1 May 2026
- A dual-function variant on chromosome 17 regulates circRNA expression and splicing in multiple sclerosis Preprint · 20 Mar 2026
- Heme limitation induces LHR2, an essential gene for Leishmania pathogenesis Article · 25 Feb 2026
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- Tracing the molecular route to progression in miRNA-biogenesis-defective thyroid lesions Article · 9 Feb 2026
- The impact of vasectomy on the seminal microbiome: possible implications and source of microbes Article · 2026
- Unraveling the molecular landscape of Erdheim–Chester disease: new insights from methylome and transcriptome integration Article · 21 Aug 2025
- Human Papillomavirus-Encoded microRNAs as Regulators of Human Gene Expression in Anal Squamous Cell Carcinoma: A Meta-Transcriptomics Study Article · 9 Jun 2025
- CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus Article · 10 Feb 2025
- Genome drafts of Lotmaria passim strains C2 and C3 isolated from honey bees in Spain Article · 16 Jan 2025
- Gut microbiome and clinical and lifestyle host factors associated with recurrent positive RT-PCR for SARS-CoV-2 Article · 18 Dec 2024
- A Strong Dysregulated Myeloid Component in the Epigenetic Landscape of Systemic Sclerosis: An Integrated DNA Methylome and Transcriptome Analysis Article · 12 Dec 2024
- Exercise and tumor proteome: Insights from a neuroblastoma model Article · 1 Dec 2024
- Expanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing Article · Dec 2024
- COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation Article · 28 Nov 2024
- Multi-omics framework to reveal the molecular determinants of fermentation performance in wine yeast populations Article · 15 Oct 2024
- O-305 Mapping the entire functionally active seminal microbiota and its association with semen quality parameters Article · 1 Jul 2024
- O-268 Re-considering the endometrial microbiome: a comparison of DNA- and RNA-based sequencing techniques within the same cohort Article · 1 Jul 2024
- Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes Article · Jun 2024
- POS0256 THE FIRST METHYLOME PROFILING STUDY OF B-CELLS IN IGA VASCULITIS REVEALED POTENTIAL BIOMARKERS OF DISEASE SUSCEPTIBILITY Article · Jun 2024
- POS0056 UNVEILING VASCULAR, PRO-FIBROTIC AND INTERFERON-RELATED ABNORMALITIES THROUGH AN EPIGENOME-WIDE ANALYSIS IN SYSTEMIC SCLEROSIS Article · Jun 2024
- OP0025 GENOME-WIDE DNA METHYLATION STUDY REVEALS SPECIFIC SIGNATURES IN THE AFFECTED ARTERIAL TISSUE OF GIANT CELL ARTERITIS PATIENTS Article · Jun 2024
- A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model Article · 23 Feb 2024
- miRNAs, Human Health and Diseases Book / chapter · 2024
- Inter-kingdom Signalling: Exploring the Relationships Among Microorganisms and MicroRNAs in Human Health Book / chapter · 2024
- A holistic approach to understanding immune-mediated inflammatory diseases: bioinformatic tools to integrate omics data Article · 28 Nov 2023
- Multi‐omic study to unmask genes involved in prostate cancer development in a multi‐case family Article · 21 Nov 2023
- Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection Article · 20 Oct 2023
- Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity Article · 4 Oct 2023
- THE NEUROPEPTIDE CORTISTATIN REGULATES THE PROGRAMMING OF BRAIN ENDOTHELIAL CELLS UNDER PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS Article · Oct 2023
- Explainable artificial intelligence to predict and identify prostate cancer tissue by gene expression Article · Oct 2023
- Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms Article · Sep 2023
- reanalyzerGSE: tackling the everlasting lack of reproducibility and reanalyses in transcriptomics Preprint · 13 Jul 2023
- P-366 Unraveling the whole transcriptome profiles of receptive phase endometrium in infertile women Article · 1 Jun 2023
- POS0093 TRANSCRIPTOMIC AND METHYLOMIC PROFILING OF CD4+ T-CELLS IN GIANT CELL ARTERITIS WITH DIFFERENT DISEASE ACTIVITY Article · Jun 2023
- Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate Article · 15 Feb 2023
- Comparison of Metagenomics and Metatranscriptomics Tools: A Guide to Making the Right Choice Article · 3 Dec 2022
- FUNCTIONALLY ACTIVE MICROBIOTA LANDSCAPE IN RECURRENT IMPLANTATION FAILURE Article · Oct 2022
- Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids Article · Sep 2022
- Pluripotency factors regulate the onset of Hox cluster activation in the early embryo Article · 15 Jul 2022
- P-431 Functionally active microbiota in the receptive-phase endometria in women with recurrent implantation failure Article · 29 Jun 2022
- Transcriptome Analysis of Intracellular Amastigotes of Clinical Leishmania infantum Lines from Therapeutic Failure Patients after Infection of Human Macrophages Article · 27 Jun 2022
- Modulation of Cholesterol Pathways in Human Macrophages Infected by Clinical Isolates of Leishmania infantum Article · 29 Apr 2022
- RNA-Seq, Bioinformatic Identification of Potential MicroRNA-like Small RNAs in the Edible Mushroom Agaricus bisporus and Experimental Approach for Their Validation Article · 28 Apr 2022
- Epigenetic changes in the metabolically healthy obese: A case‐control versus a prospective study Article · 11 Apr 2022
- Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1 Article · 30 Mar 2022
- Identification of Group II Intron RmInt1 Binding Sites in a Bacterial Genome Article · 25 Feb 2022
- Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic‐ and cholestatic‐induced liver injury Article · 10 Feb 2022
- Differently Regulated Gene-Specific Activity of Enhancers Located at the Boundary of Subtopologically Associated Domains: TCRα Enhancer Article · Feb 2022
- Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis Article · 28 Jan 2022
- Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses Preprint · 21 Dec 2021
- Maternal high fat diets based on olive oil protect offspring against nafld features through epigenetic alterations Article · Dec 2021
- GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels Article · 29 Oct 2021
- CD38 Deficiency Ameliorates Chronic Graft-Versus-Host Disease Murine Lupus via a B-Cell-Dependent Mechanism Article · 24 Aug 2021
- Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma Article · 3 Aug 2021
- Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer Article · 5 Jun 2021
- The Implications of ncRNAs in the Development of Human Diseases Article · 24 Feb 2021
- Mapping the entire functionally active endometrial microbiota Article · 18 Feb 2021
- NGS Methodologies and Computational Algorithms for the Prediction and Analysis of Plant Circular RNAs Book / chapter · 2021
- The PARP Inhibitor Olaparib Modulates the Transcriptional Regulatory Networks of Long Non-Coding RNAs during Vasculogenic Mimicry Article · 15 Dec 2020
- Single cell profiling of COVID-19 patients: an international data resource from multiple tissues Preprint · 23 Nov 2020
- P14 Nuevas alteraciones transcripcionales en la patogenia de la diabetes tipo 2 y posible regulación por micro ARNs Article · 21 Nov 2020
- Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci Article · 25 Sep 2020
- Evidence for a role of phenotypic mutations in virus adaptation Preprint · 22 Aug 2020
- An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogenesis Article · 5 Jun 2020
- SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes Article · 6 Nov 2019
- A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection Article · Oct 2019
- Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma Article · 26 Mar 2019
- SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition Article · 4 Sep 2018
- Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci Article · 15 Aug 2018
- CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism Article · 20 Feb 2018
- Application of iTRAQ shotgun proteomics for revealing metabolic changes related to Gaucher disease Article · Feb 2018
- Corrigendum: miARma-Seq: a comprehensive tool for miRNA, mRNA and circRNA analysis Article · 8 Jan 2018
- The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity Article · Jan 2018
- Novel miRNA-mRNA interactions conserved in essential cancer pathways Article · 7 Apr 2017
- Prediction of miRNA-mRNA interactions using miRGate Book / chapter · 2017
- Preliminary data on the successful micronucleus testing with the EPISKIN® reconstructed epidermis model Article · Sep 2016
- Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer Article · 15 Jul 2016
- miARma-Seq: a comprehensive tool for miRNA, mRNA and circRNA analysis Software · 11 May 2016
- MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression Article · 25 Feb 2016
- The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons Article · 29 Dec 2015
- Lower-normal TSH is associated with better metabolic risk factors: A cross-sectional study on Spanish men Article · Dec 2015
- Prp40 and early events in splice site definition Article · 23 Oct 2015
- Tumor MicroRNA Expression Profiling Identifies Circulating MicroRNAs for Early Breast Cancer Detection Article · 1 Aug 2015
- miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors Article · Mar 2015
- miRGate: a curated database of human, mouse and rat miRNA-mRNA targets Software · 1 Jan 2015
- Lipoprotein(a) levels in familial hypercholesterolemia: an important predictor of cardiovascular disease independent of the type of LDL receptor mutation. Article · May 2014
- The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma Article · 14 Apr 2014
- MicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours Article · 8 Oct 2013
- ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data Article · 7 Nov 2012
- Getting deep in the luminal B breast cancer subtype and its ki67 cut-off value Article · 16 Nov 2011
- 5116 POSTER Evidence of No Benefit for Extensive Axillary Dissection in Lymph Node-positive Early Breast Cancer Treated With Adjuvant Radiation Article · Sep 2011
- Epstein-Barr virus microRNAs repress BCL6 expression in diffuse large B-cell lymphoma Article · 26 Jul 2011
- Luminal B breast cancer and prognostic value of HER2 overexpression: Retrospective analysis of a single-institution series. Article · 20 May 2011
- Inference of Functional Relations in Predicted Protein Networks with a Machine Learning Approach Article · 1 Apr 2010
- EcID. A database for the inference of functional interactions in E. coli. Article · 1 Jan 2009
- Prediction of protein interaction based on similarity of phylogenetic trees. Book / chapter · 2008
- Intelligent client for integrating bioinformatics services Article · 27 Oct 2005
- Text mining for metabolic pathways, signaling cascades, and protein networks. Article · 10 May 2005
- Evaluation of BioCreAtIvE assessment of task 2 Article · May 2005
