Detalle de: THE NEUROPEPTIDE CORTISTATIN REGULATES THE PROGRAMMING OF BRAIN ENDOTHELIAL CELLS UNDER PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS

The critical brain activity governing cognition, behaviour, and coordination of the peripheral organs requires a fine-tuned microenvironment based on the regulated influx and efflux of ions, oxygen and nutrients to and from the brain compartments, and a restricted invasion of toxins and pathogens. For this, a tightly controlled blood-brain barrier (BBB) is essential as its breakdown and subsequent disturbance of brain function is involved in a variety of central nervous system diseases. Endothelial cells from brain microvasculature are the main responsible of sustaining BBB formation and stability but also may be a cause or consequence of BBB dysfunction.