Detalle de: Diversity of Quaternary Structures Regulates Nuclear Receptor Activities.
| Title | Diversity of Quaternary Structures Regulates Nuclear Receptor Activities. |
| Abstract |
Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein complexes, which activate or repress gene transcription to regulate development, homeostasis, and metabolism. Recent studies on NR quaternary structure reveal novel mechanisms of receptor dimerization, the existence of tetrameric chromatin-bound NRs, and previously unanticipated protein-protein/protein-DNA interactions. |
| Apa Reference | Fuentes-Prior, P., Rojas, A., Hagler, A. T., & Estébanez-Perpiñá, E. (2019). Diversity of Quaternary Structures Regulates Nuclear Receptor Activities. Trends in Biochemical Sciences, 44(1), 2–6. 10.1016/j.tibs.2018.09.005 |
| Doi | 10.1016/j.tibs.2018.09.005 |
| Publication Date | Jan 2019 |
| Publication Type | Article |
| Researcher | Ana Rojas |
| Ontology | Large language models, Functional genomics, Structural bioinformatics, Molecular evolution |
| Research Groups | Computational Biology and Bioinformatics (CBBIO.CABD) |
| Tools |