Detalle de: SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
| Title | SPOC: A widely distributed domain associated with cancer, apoptosis and transcription |
| Abstract |
Background The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. Results We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. Conclusions The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality. |
| Apa Reference | Sánchez-Pulido, L., Rojas, A. M., van Wely, K. H., Martinez-A, C., & Valencia, A. (2004). SPOC: A widely distributed domain associated with cancer, apoptosis and transcription. BMC Bioinformatics, 5(1). 10.1186/1471-2105-5-91 |
| Doi | 10.1186/1471-2105-5-91 |
| Publication Date | 7 Jul 2004 |
| Publication Type | Article |
| Researcher | Ana Rojas |
| Ontology | Large language models, Functional genomics, Structural bioinformatics, Molecular evolution |
| Research Groups | Computational Biology and Bioinformatics (CBBIO.CABD) |
| Tools |