Detalle de: The occurrence of type S1A serine proteases in sponge and jellyfish

Although serine proteases are found in all kinds of cellular organisms and many viruses, the classic "chymotrypsin family" (Group S1A by the 1998 Barrett nomenclature) has an unusual phylogenetic distribution, being especially common in animals, entirely absent from plants and protists, and rare among fungi. The distribution in Bacteria is largely restricted to the genus Streptomyces, although a few isolated occurrences in other bacteria have been reported. The family may be entirely absent from Archaea. Although more than a thousand sequences have been reported for enzymes of this type from animals, none of them have been from early diverging phyla like Porifera or Cnidaria. We now report the existence of Group S1A serine proteases in a sponge (phylum Porifera) and a jellyfish (phylum Cnidaria), making it safe to conclude that all animal groups possess these enzymes.