Detalle de: Regulation of the Ebola Virus VP24 protein by SUMO
| Title | Regulation of the Ebola Virus VP24 protein by SUMO |
| Abstract |
The Ebola virus VP24 protein plays a critical role in escape of the virus from the host innate immune response. Therefore, deciphering the molecular mechanisms modulating VP24 activity may be useful to identify potential targets amenable to therapeutics. Here, we identify the cellular proteins USP7, SUMO, and ubiquitin as novel interactors and regulators of VP24. These interactions may represent novel potential targets to design new antivirals with the ability to modulate Ebola virus replication. |
| Apa Reference | Vidal, S., El Motiam, A., Seoane, R., Preitakaite, V., Bouzaher, Y. H., Gómez-Medina, S., San Martín, C., Rodríguez, D., Rejas, M. T., Baz-Martínez, M., Barrio, R., Sutherland, J. D., Rodríguez, M. S., Muñoz-Fontela, C., & Rivas, C. (2019). Regulation of the Ebola Virus VP24 Protein by SUMO. Journal of Virology, 94(1). 10.1128/jvi.01687-19 |
| Doi | 10.1128/JVI.01687-19 |
| Publication Date | 12 Dec 2019 |
| Publication Type | Article |
| Researcher | Carmen San Martín |
| Ontology | |
| Research Groups | Structural and physical determinants of complex virus assembly |
| Tools |