Carmen San Martín
Structural and physical determinants of complex virus assembly · CNB
Biography
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We are interested in the structural and physical principles that govern assembly and stabilisation of complex viruses. As a model system we use adenovirus, a challenging specimen of interest both in basic virology and in nanobiomedicine. We are also interested in assembly of complex marine viruses structurally related to adenovirus. We approach the problem from an interdisciplinary point of view, combining biophysics, computational, structural and molecular biology techniques. Accurate knowledge of virus structure and biology is fundamental to both the discovery of antiviral drugs and the design of new, efficient virus-based biotechnological tools. |
Profile
| Institution | CNB |
| Position | CSIC Research Professor |
| Home page | https://www.cnb.csic.es/investigacion/departamentos/estructura-macromoleculas/complex-virus-assembly/ |
| Contact email | carmen@cnb.csic.es |
| ORCID | 0000-0001-9799-175X |
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Research
Research topics
Computational MethodsStructural bioinformaticsExperimental structure determinationStructure prediction
Research lines
Projects, networks, transfer & teaching
Research networks
International
- Coordinator of Spanish Adenovirus Network (AdenoNet) https://sites.google.com/site/adenonet/
Teaching
Master programs
- MSc in Virology - Universidad Complutense de Madrid
- MSc in Biomolecules and Cell Dynamics - Universidad Autónoma de Madrid
Publications 80 entries
- Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence Article · 23 Sep 2026
- Structure of NO16, a marine non-tailed vibriophage with an unusual symmetry-mismatched vertex arrangement Article · 8 Sep 2026
- Rab9 depletion enhances human adenovirus type 26 transduction efficiency through increased internalization and reduced late endosomal/lysosomal retention Article · 10 Aug 2026
- Protease-driven remodeling of stabilization networks during adenovirus assembly Preprint · 4 Aug 2026
- Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins Article · 9 Oct 2025
View all (75 more)
- Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Animal DNA Viruses and Retroviruses Subcommittee, 2025 Article · 25 Jul 2025
- Haptophyte-infecting viruses change the genome condensing proteins of dinoflagellates Preprint · 30 Jan 2025
- Structural biology of adenovirus Book / chapter · 2025
- Maturation of Viruses Book / chapter · 2024
- Architecture and Assembly of Structurally Complex Viruses Book / chapter · 2024
- Physical Virology in Spain Article · 31 Oct 2023
- Adenovirus core protein V reinforces the capsid and enhances genome release from disrupted particles Article · 7 Apr 2023
- Surface characterization of alkane viral anchoring films prepared by titanate-assisted organosilanization Article · Feb 2023
- RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa Article · 16 Jun 2022
- ICTV Virus Taxonomy Profile: Adenoviridae 2022 Article · 30 Mar 2022
- Seeing and touching adenovirus: complementary approaches for understanding assembly and disassembly of a complex virion Article · Feb 2022
- Acidification induces condensation of the adenovirus core Article · Nov 2021
- Bromodeoxyuridine Labelling to Determine Viral DNA Localization in Fluorescence and Electron Microscopy: The Case of Adenovirus Article · 18 Sep 2021
- Adenovirus Structure: What Is New? Article · 15 May 2021
- Long-Range Cooperative Disassembly and Aging During Adenovirus Uncoating Article · 30 Apr 2021
- Near-atomic structure of an atadenovirus reveals a conserved capsid-binding motif and intergenera variations in cementing proteins Article · 2 Apr 2021
- Fluctuating nonlinear spring theory: Strength, deformability, and toughness of biological nanoparticles from theoretical reconstruction of force-deformation spectra: Fluctuating Nonlinear Spring theory strength and toughness of virus particles Article · Mar 2021
- Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenoviruses Article · 26 Feb 2021
- Adenoviruses (Adenoviridae) and Their Structural Relatives Book / chapter · 2021
- VIRUCIDAL ACTION MECHANISM OF ALCOHOL AND DIVALENT CATIONS AGAINST HUMAN ADENOVIRUS Article · 17 Dec 2020
- Dynamic competition for hexon binding between core protein VII and lytic protein VI promotes adenovirus maturation and entry Article · 28 May 2020
- Multifunctional carbon nanotubes covalently coated with imine-based covalent organic frameworks: exploring structure–property relationships through nanomechanics Article · 2020
- Regulation of the Ebola Virus VP24 protein by SUMO Article · 12 Dec 2019
- Adenovirus major core protein condenses DNA in clusters and bundles, modulating genome release and capsid internal pressure Article · 9 Aug 2019
- Virus Maturation Book / chapter · 2019
- The so far farthest reaches of the double jelly roll capsid protein fold Article · 23 Nov 2018
- Structural and mechanical characterization of viruses with AFM Book / chapter · 30 Oct 2018
- Structure of a Reptilian Adenovirus Reveals a Phage Tailspike Fold Stabilizing a Vertebrate Virus Capsid Article · Oct 2017
- Role of Condensing Particles in Polymer Confinement: A Model for Virus-Packed “Minichromosomes” Article · Oct 2017
- Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly and packaging occur concurrently at the periphery of the replication center Article · 27 Apr 2017
- Albumin-binding adenoviruses circumvent pre-existing neutralizing antibodies upon systemic delivery Article · Sep 2016
- Mechanics of Viral Chromatin Reveals the Pressurization of Human Adenovirus Article · 28 Oct 2015
- Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses Article · 24 Sep 2015
- Structures of adenovirus incomplete particles clarify capsid architecture and show maturation changes of packaging protein L1 52/55k Article · 15 Sep 2015
- Transmission electron microscopy and the molecular structure of icosahedral viruses Article · Sep 2015
- Distribution of DNA-condensing protein complexes in the adenovirus core Article · 27 Mar 2015
- Correction: Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1 Article · 25 Mar 2015
- Quantitative nanoscale electrostatics of viruses Article · 2015
- Crystal structure of the fibre head domain of the atadenovirus snake adenovirus 1 Article · 8 Dec 2014
- Structure, function and dynamics in adenovirus maturation Article · 21 Nov 2014
- Molecular characterization of a lizard adenovirus reveals the first atadenovirus with two fiber genes and the first adenovirus with either one short or three long fibers per penton Article · Oct 2014
- Processing of the L1 52/55k protein by the adenovirus protease: A new substrate and new insights into virion maturation Article · Feb 2014
- Crystallization of the C-terminal domain of the fibre protein from snake adenovirus 1, an atadenovirus Article · 29 Nov 2013
- Biophysical methods to monitor structural aspects of the adenovirus infectious cycle Book / chapter · 24 Sep 2013
- Monitoring dynamics of human adenovirus disassembly induced by mechanical fatigue Article · 13 Mar 2013
- Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space Article · Jan 2013
- Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction Article · Jan 2013
- Structure and assembly of complex viruses Book / chapter · 2013
- San Martín, C., Correction: Latest Insights on Adenovirus Structure and Assembly. Viruses 2012, 4, 847-877. Article · 19 Dec 2012
- The role of capsid maturation on adenovirus priming for sequential uncoating Article · Sep 2012
- Latest insights on adenovirus structure and assembly Article · 21 May 2012
- Minimizing tip-sample forces in jumping mode atomic force microscopy in liquid Article · Mar 2012
- Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses Article · Jun 2011
- Self-inactivating helper virus for the production of high-capacity adenoviral vectors Article · 28 Apr 2011
- Structure and Uncoating of Immature Adenovirus Article · Sep 2009
- Automatic particle selection from electron micrographs using machine learning techniques Article · Sep 2009
- Localization of the N-Terminus of Minor Coat Protein IIIa in the Adenovirus Capsid Article · Nov 2008
- Infectious bursal disease virus capsid assembly and maturation by structural rearrangements of a transient molecular switch Article · Jul 2007
- Polymorphism and double hexamer structure in the archaeal minichromosome maintenance (MCM) helicase from Methanobacterium thermoautotrophicum Article · Dec 2005
- Double hexamer disruption and biochemical activities of Methanobacterium thermoautotrophicum MCM Article · Dec 2005
- Classification of single-projection reconstructions for cryo-electron microscopy data of icosahedral viruses Article · Jul 2005
- Insights into assembly from structural analysis of bacteriophage PRD1 Article · Nov 2004
- Minor proteins, mobile arms and membrane–capsid interactions in the bacteriophage PRD1 capsid Article · 9 Sep 2002
- Combined EM/X-Ray Imaging Yields a Quasi-Atomic Model of the Adenovirus-Related Bacteriophage PRD1 and Shows Key Capsid and Membrane Interactions Article · Oct 2001
- Polymorphic quaternary organization of the Bacillus subtilis bacteriophage SPP1 replicative helicase (G40P) Article · Nov 1998
- Six molecules of SV40 large T antigen assemble in a propeller-shaped particle around a channel Article · Apr 1997
- Electron Tomography of Biological Specimens Book / chapter · 1997
- Xmipp: An image processing package for electron microscopy Article · Jan 1996
- Cpn60 is exclusively localized into mitochondria of rat liver and embryonic Drosophila cells Article · Oct 1995
- A Structural Model for the Escherichia coli DnaB Helicase Based on Electron Microscopy Data Article · May 1995
- Characterization of a human astrovirus serotype 2 structural protein (VP26) that contains an epitope involved in virus neutralization Article · Jun 1994
- TOPOGRAPHICAL ANALYSIS OF CANINE PARVOVIRUS VIRIONS AND RECOMBINANT VP2 CAPSIDS Article · 1 Sep 1993
- Subcellular localization of type I thionins in the endosperms of wheat and barley Article · Mar 1993
- A structural model for the GroEL chaperonin Article · Feb 1993
- 1,2-Dioleoylglycerol promotes calcium-induced fusion in phospholipid vesicles Article · Oct 1992