Detalle de: A region containing repeated elements is associated with transcriptional termination of Leishmania infantum ribosomal RNA genes
| Title | A region containing repeated elements is associated with transcriptional termination of Leishmania infantum ribosomal RNA genes |
| Abstract |
A novel repetitive DNA element has been isolated from the Leishmania infantum genome. The 348 bp long element, designated LiR3, was found to be located downstream from the 3'-end of the ribosomal RNA (rRNA) genes. This LiR3 element has short sequences with potential to form stem-loop structures similar to those of the bacterial rho-independent transcriptional terminators. Given both the structural features and the genomic location of this element we searched for a possible functional implication of these structures in the termination of rRNA transcription. Nuclear run-on assays indicated that indeed there is a transcriptional blockage associated with the LiR3 element. Several chi-like elements, resembling the recombination-promoting sites of Escherichia coli, were identified within the sequences associated with the stem-loop structures. A possible implication of these chi-like elements in rRNA gene conversion events is discussed. |
| Apa Reference | Requena, J. M., Soto, M., Quijada, L., Carrillo, G., & Alonso, C. (1997). A region containing repeated elements is associated with transcriptional termination of Leishmania infantum ribosomal RNA genes1Note: Nucleotide sequences data reported in this paper are available in the EMBL, GenBank™ and DDJB data bases under the accession number X99114.1. Molecular and Biochemical Parasitology, 84(1), 101–110. 10.1016/s0166-6851(96)02785-5 |
| Doi | 10.1016/S0166-6851(96)02785-5 |
| Publication Date | Jan 1997 |
| Publication Type | Article |
| Researcher | José María Requena Rolanía |
| Ontology | Model organisms, Genomics |
| Research Groups | Regulation of gene expression in Leishmania |
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