Detalle de: Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl–fluoride inhibitor of serine peptidases
| Title | Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl–fluoride inhibitor of serine peptidases |
| Abstract |
The metallopeptidase ulilysin is kept latent by a cysteine-switch mechanism and is unexpectedly inhibited by the serine-peptidase inhibitor, 4-(2-aminoethyl)benzenesulfonyl fluoride. |
| Apa Reference | Rodríguez-Banqueri, A., Moliner-Culubret, M., Mendes, S. R., Guevara, T., Eckhard, U., & Gomis-Rüth, F. X. (2023). Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl–fluoride inhibitor of serine peptidases. Dalton Transactions, 52(12), 3610–3622. 10.1039/d3dt00458a |
| Doi | 10.1039/D3DT00458A |
| Publication Date | 2023 |
| Publication Type | Article |
| Researcher | Ulrich Eckhard |
| Ontology | Drug Discovery and design |
| Research Groups | Synthetic Structural Biology |
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