Detalle de: SQANTI-browser: visualization and curation of SQANTI3-classified long-read transcriptomes within the UCSC Genome Browser
| Title | SQANTI-browser: visualization and curation of SQANTI3-classified long-read transcriptomes within the UCSC Genome Browser |
| Abstract |
Long-read sequencing enables transcriptome-wide isoform discovery. However, it generates substantial technical and structural ambiguity that complicates transcript interpretation. Here, we present SQANTI-browser, a classification-aware visualization framework that converts SQANTI3 outputs into interactive UCSC Genome Browser Track Hubs, preserving full transcript structural metadata. By integrating SQANTI classifications directly within the UCSC ecosystem, SQANTI-browser enables dynamic filtering and evidence-guided curation alongside public resource tracks. Furthermore, its adaptive architecture natively supports non-reference genomes, orthogonal data, and custom metadata fields. Applied to clinical, noisy, and synthetic datasets, SQANTI-browser resolves alignment artifacts and rescues actionable novel isoforms, providing a robust framework for long-read transcriptome curation. |
| Apa Reference | Paniagua, A., Blanco, C., Colomer Fernández, A., Diekhans, M., Conesa, A. & Monzó, C. (2026). SQANTI-browser: visualization and curation of SQANTI3-classified long-read transcriptomes within the UCSC Genome Browser. 10.64898/2026.05.25.727625 |
| Doi | 10.64898/2026.05.25.727625 |
| Publication Date | 28 May 2026 |
| Publication Type | Preprint |
| Researcher | Ana Conesa |
| Ontology | Transcriptomics, Data Visualization, Genome Assembly, Long-read sequencing |
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