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Orcid Publication

Detalle de: SQANTI-browser: visualization and curation of SQANTI3-classified long-read transcriptomes within the UCSC Genome Browser

Title SQANTI-browser: visualization and curation of SQANTI3-classified long-read transcriptomes within the UCSC Genome Browser
Abstract

Long-read sequencing enables transcriptome-wide isoform discovery. However, it generates substantial technical and structural ambiguity that complicates transcript interpretation. Here, we present SQANTI-browser, a classification-aware visualization framework that converts SQANTI3 outputs into interactive UCSC Genome Browser Track Hubs, preserving full transcript structural metadata. By integrating SQANTI classifications directly within the UCSC ecosystem, SQANTI-browser enables dynamic filtering and evidence-guided curation alongside public resource tracks. Furthermore, its adaptive architecture natively supports non-reference genomes, orthogonal data, and custom metadata fields. Applied to clinical, noisy, and synthetic datasets, SQANTI-browser resolves alignment artifacts and rescues actionable novel isoforms, providing a robust framework for long-read transcriptome curation.

Apa Reference Paniagua, A., Blanco, C., Colomer Fernández, A., Diekhans, M., Conesa, A. & Monzó, C. (2026). SQANTI-browser: visualization and curation of SQANTI3-classified long-read transcriptomes within the UCSC Genome Browser. 10.64898/2026.05.25.727625
Doi 10.64898/2026.05.25.727625
Publication Date 28 May 2026
Publication Type Preprint
Researcher Ana Conesa
Ontology Transcriptomics, Data Visualization, Genome Assembly, Long-read sequencing
Research Groups
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