Detalle de: Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition
| Title | Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition |
| Abstract |
A novel protocol has been established to prepare the kanamycin ring II/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6′) and APH-(3′) binder, and as a poor substrate for the ravenous ANT-(4′), makes it an excellent candidate for the design of inhibitors of these aminoglycoside modifying enzymes. |
| Apa Reference | Zárate, S.G., Bastida, A., Santana, A.G. & Revuelta, J. (2019). Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition. Antibiotics, 8(3), 109. 10.3390/antibiotics8030109 |
| Doi | 10.3390/antibiotics8030109 |
| Publication Date | 2 Aug 2019 |
| Publication Type | Article |
| Researcher | Agatha Bastida |
| Ontology | Sequence analysis, Drug Discovery and design, Development |
| Research Groups | |
| Tools |