Agatha Bastida
Biography
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Tenured Scientist (Científica Titular) at the CSIC since July 2006, at the Instituto de Química Orgánica General (IQOG-CSIC), Madrid. Previously at the Instituto de Catálisis y Petroleoquímica (ICP-CSIC) (1994-2013) and at Unilever, UK (1993-1994). (Description curated from publicly available data.) |
Profile
| Institution | IQOG |
| Position | Tenured Scientist |
| Home page | https://github.com/agathabastida |
| Contact email | agatha.bastida@csic.es |
| ORCID | 0000-0002-5141-9595 |
BCB Hub
| BCB Committee | Talent attraction and training, Teaching links with University |
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| BCB Services |
Research
Research topics
None
Projects, networks, transfer & teaching
Teaching
Master programs
- MSc in Bioinformatics - Universidad Europea - https://universidadeuropea.com/master-bioinformatica-online/ (BCB coordinator)
- MSc in Industrial Biotechnology - Universidad Complutense de Madrid (BCB coordinator)
- Master en Biotecnologia Industrial - Universidad Complutense de Madrid (BCB coordinator)
Publications 71 entries
- Molecular Modelling of Novel Selective Inhibitors of Mycobacterium tuberculosis CYP125A1 Protein Based on Natural Product-like Structures Article · 24 Jan 2025
- Use of supramolecular chemistry based on β-cyclodextrin-grafted chitosan beads to prepare green biocatalytic materials Article · 2025
- Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer Article · 12 Nov 2024
- Computational Biology Dynamics of Mps1 Kinase Molecular Interactions with Isoflavones Reveals a Chemical Scaffold with Potential to Develop New Therapeutics for the Treatment of Cancer Article · 17 Nov 2022
- Identification of Novel Potential Heparanase Inhibitors Using Virtual Screening Article · 30 Apr 2022
View all (66 more)
- Identification of New Dioxygenases Able to Recognize Polycyclic Aromatic Hydrocarbons with High Aromaticity Article · 2 Mar 2022
- Biodiversidad bacteriana presente en suelos contaminados con hidrocarburos para realizar biorremediación Article · 1 Jan 2022
- A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria Article · Jan 2022
- Novel SH-SAW Biosensors for Ultra-Fast Recognition of Growth Factors Article · 30 Dec 2021
- Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli Article · 28 Sep 2021
- De Novo Design of Selective Quadruplex–Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot‐Spot Article · 22 Feb 2021
- Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of Their Biological Functions Article · 19 Jan 2021
- Heparanized chitosans: towards the third generation of chitinous biomaterials Article · 2021
- Interfering with mRNA Methylation by the 2′O-Methyltransferase (NSP16) from SARS-CoV-2 to Tackle the COVID-19 Disease Article · 5 Sep 2020
- Biocatalysis: Chemical Biosynthesis Article · 2 Apr 2020
- Inhibition–Disruption of Candida glabrata Biofilms: Symmetrical Selenoesters as Potential Anti-Biofilm Agents Article · 9 Dec 2019
- Pseudokinases: From Allosteric Regulation of Catalytic Domains and the Formation of Macromolecular Assemblies to Emerging Drug Targets Article · 19 Sep 2019
- Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition Article · 2 Aug 2019
- Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals Article · 1 Apr 2019
- A Molecular Modeling Approach to Identify Novel Inhibitors of the Major Facilitator Superfamily of Efflux Pump Transporters Article · 15 Mar 2019
- Theoretical Studies on Mechanism of Inactivation of Kanamycin A by 4′-O-Nucleotidyltransferase Article · 29 Jan 2019
- A holistic approach to unravelling chondroitin sulfation: Correlations between surface charge, structure and binding to growth factors Article · Dec 2018
- Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics Article · Jul 2018
- Biochemical profiling of rat embryonic stem cells grown on electrospun polyester fibers using synchrotron infrared microspectroscopy Article · 18 Apr 2018
- Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors Article · 30 Jan 2018
- Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics Article · 2018
- Highly improved enzymatic peptide synthesis by using biphasic reactors Article · 20 May 2017
- Microfluidic Reactors Based on Rechargeable Catalytic Porous Supports: Heterogeneous Enzymatic Catalysis via Reversible Host–Guest Interactions Article · 17 Jan 2017
- Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders Article · 11 May 2016
- Selective modification of the 3′′-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains Article · 2016
- 6- O -Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine Article · 2016
- Modulating Weak Interactions for Molecular Recognition: A Dynamic Combinatorial Analysis for Assessing the Contribution of Electrostatics to the Stability of CH–π Bonds in Water Article · 9 Feb 2015
- A thorough experimental study of CH/π interactions in water: quantitative structure–stability relationships for carbohydrate/aromatic complexes Article · 2015
- Aryl Sulfotransferase from Haliangium ochraceum : A Versatile Tool for the Sulfation of Small Molecules Article · 26 Mar 2014
- Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design Article · 7 Feb 2013
- Multiple Keys for a Single Lock: The Unusual Structural Plasticity of the Nucleotidyltransferase (4′)/Kanamycin Complex Article · Feb 2012
- Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease Article · Sep 2011
- Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles Article · Jan 2011
- An Efficient and General Route to the Synthesis of Novel Aminoglycosides for RNA Binding Article · Jan 2011
- Role of Aromatic Rings in the Molecular Recognition of Aminoglycoside Antibiotics: Implications for Drug Design Article · 10 Aug 2010
- The Unusual Nucleotide Recognition Properties of the Resistance Enzyme ANT(4′): Inorganic Tri/Polyphosphate as a Substrate for Aminoglycoside Inactivation Article · 29 Jul 2010
- Structure‐Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics Article · Mar 2010
- Role of Conserved Salt Bridges in Homeodomain Stability and DNA Binding Article · Aug 2009
- From Kinase to Cyclase: An Unusual Example of Catalytic Promiscuity Modulated by Metal Switching Article · 15 Jan 2009
- NMR-Based Analysis of Aminoglycoside Recognition by the Resistance Enzyme ANT(4′): The Pattern of OH/NH 3 + Substitution Determines the Preferred Antibiotic Binding Mode and Is Critical for Drug Inactivation Article · 26 Mar 2008
- The Pattern of Distribution of Amino Groups Modulates the Structure and Dynamics of Natural Aminoglycosides: Implications for RNA Recognition Article · 14 Feb 2007
- Rescue of the streptomycin antibiotic activity by using streptidine as a “decoy acceptor” for the aminoglycoside-inactivating enzyme adenyl transferase Article · 2007
- A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer Article · 2007
- Studies on the Conformational Features of Neomycin-B and its Molecular Recognition by RNA and Bacterial Defense Proteins Book / chapter · 2007
- Exploring the Use of Conformationally Locked Aminoglycosides as a New Strategy to Overcome Bacterial Resistance Article · 14 Dec 2005
- Molecular Recognition of Aminoglycoside Antibiotics by Bacterial Defence Proteins: NMR Study of the Structural and Conformational Features of Streptomycin Inactivation by Bacillus subtilis Aminoglycoside‐6‐adenyl Transferase Article · 9 Aug 2005
- A Simple Structural-Based Approach to Prevent Aminoglycoside Inactivation by Bacterial Defense Proteins. Conformational Restriction Provides Effective Protection against Neomycin-B Nucleotidylation by ANT4 Article · 17 May 2005
- Structure / Activity Relationship of Carba- and C-Fucopyranosides as Inhibitors of an α 1,6-Fucosyltransferase by Molecular Modeling and Kinetic Studies Article · 1 May 2005
- Synthesis, Inhibition Properties, and Theoretical Study of the New Nanomolar Trehalase Inhibitor 1‐Thiatrehazolin: Towards a Structural Understanding of Trehazolin Inhibition Article · 7 Jan 2005
- Enzymes in the synthesis of bioactive compounds Article · Apr 2004
- In Vivo Chaperone‐Assisted Folding of α ‐1,6‐Fucosyltransferase from Rhizobium sp. Article · 2 Jun 2003
- Synthesis of the aminocyclopentitol moieties of the hopanoids of Zymomonas mobilis and ‘Anacystis montana’ Article · 2003
- Regioselective enzymatic hydrolysis of acetylated pyranoses and pyranosides using immobilised lipases. An easy chemoenzymatic synthesis of α- and β-d-glucopyranose acetates bearing a free secondary C-4 hydroxyl group Article · Oct 2002
- C-Terminal truncation of α 1,6-fucosyltransferase from Rhizobium sp. does not annul the transferase activity of the enzyme Article · Mar 2002
- Modulation of lipase properties in macro-aqueous systems by controlled enzyme immobilization: enantioselective hydrolysis of a chiral ester by immobilized Pseudomonas lipase Article · Mar 2001
- Biocatalyst engineering exerts a dramatic effect on selectivity of hydrolysis catalyzed by immobilized lipases in aqueous medium Article · Jan 2001
- Regioselective hydrolysis of peracetylated α-D-glucopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis Article · Feb 1999
- Reactivation strategies by unfolding/refolding of chymotrypsin derivatives after inactivation by organic solvents Article · Apr 1997
- Syntheses of pharmaceutical oligosaccharides catalyzed by immobilized-stabilized derivatives of different β-galactosidases Article · Oct 1993
- Preparation of activated supports containing low pK amino groups. A new tool for protein immobilization via the carboxyl coupling method Article · Jul 1993
- Stabilization of Soluble Proteins by Intramolecular Crosslinking with Polyfunctional Macromolecules. Poly-(Glutaraldehyde-Like) Structure Book / chapter · 1993
- Enzyme Stabilization by Multipoint Covalent Attachment to Activated Pre-Existing Supports Book / chapter · 1993
- Fully Dispersed and Covalently Attached Chymotrypsin Derivatives as Industrial Catalysts in Biphasic Systems Article · Nov 1992
- Effect of immiscible organic solvents on activity/stability of native chymotrypsin and immobilized‐stabilized derivatives Article · 5 Jan 1992
- Insolubilized Enzyme Derivatives in Organic Solvents: Mechanisms of Inactivation and Strategies for Reactivation Book / chapter · 1992
- Immobilization‐stabilization of α‐chymotrypsin by covalent attachment to aldehyde‐agarose gels Article · 5 Dec 1991