Detalle de: Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design
| Title | Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design |
| Abstract |
When you're in a (RNA) bind: An NMR-based method to explore the reactivity of ligand/RNA complexes can be used as source of valuable information for drug design. By combining NMR spectroscopy and a simple isotopic labeling strategy (see picture), positional chemical reactivity information can be readily extracted from complex aminoglycoside mixtures. C green, N blue, O red, Me purple. |
| Apa Reference | Jiménez‐Moreno, E., Gómez‐Pinto, I., Corzana, F., Santana, A.G., Revuelta, J., Bastida, A., Jiménez‐Barbero, J., González, C. & Asensio, J.L. (2013). Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design. Angewandte Chemie International Edition, 52(11), 3148-3151. 10.1002/anie.201209434 |
| Doi | 10.1002/anie.201209434 |
| Publication Date | 7 Feb 2013 |
| Publication Type | Article |
| Researcher | Agatha Bastida |
| Ontology | Experimental structure determination, Drug Discovery and design, Molecular Interactions/Docking |
| Research Groups | |
| Tools |