Detalle de: Regioselective hydrolysis of peracetylated α-D-glucopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis
| Title | Regioselective hydrolysis of peracetylated α-D-glucopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis |
| Abstract |
Penta-O-acetyl-alpha-D-glucopyranose was selectively deacetylated in aqueous media by lipases from Candida cilindracea (CCL) adsorbed on octyl-agarose support. Enzymatic hydrolyses was regioselective at the 4-position under neutral pH and towards the 6 position under acidic conditions. This enzymatic approach allows the one step synthesis of 1,2,3,6-tetra-O-acetyl-alpha-D-glucopyranoses 1, a useful intermediate in oligosaccharide synthesis. |
| Apa Reference | Bastida, A., Fernández-Lafuente, R., Fernández-Lorente, G., Guisán, J., Pagani, G. & Terreni, M. (1999). Regioselective hydrolysis of peracetylated α-D-glucopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis. Bioorganic & Medicinal Chemistry Letters, 9(4), 633-636. 10.1016/S0960-894X(99)00053-0 |
| Doi | 10.1016/S0960-894X(99)00053-0 |
| Publication Date | Feb 1999 |
| Publication Type | Article |
| Researcher | Agatha Bastida |
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