Detalle de: Structure‐Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics
| Title | Structure‐Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics |
| Abstract |
Sugar sugar! The synthesis and evaluation of ribostamycin/kanamycin hybrids incorporating a highly crowded trisubstituted aminocyclitol unit that should provide maximum complementation with the RNA receptor are reported (see picture). Analysis shows that the existing conflicts between the different sugar rings can be significantly alleviated by a simple chemical modification, leading to an improvement in activity. |
| Apa Reference | Revuelta, J., Vacas, T., Corzana, F., Gonzalez, C., Bastida, A. & Asensio, J.L. (2010). Structure‐Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics. Chemistry – A European Journal, 16(10), 2986-2991. 10.1002/chem.200903003 |
| Doi | 10.1002/chem.200903003 |
| Publication Date | Mar 2010 |
| Publication Type | Article |
| Researcher | Agatha Bastida |
| Ontology | Drug Discovery and design |
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